Analysis of Prognostic Factors in Hodgkin's Lymphoma with Regard to Response to Treatment
نویسندگان
چکیده
Hodgkin lymphoma (HL) is an uncommon malignancy involving lymph nodes and lymphatic system. Due to the progress of the treatment, HL becomes a potentially curable disease. International Prognostic Index (IPI) was defined as the number of adverse prognostic factors presented at diagnosis. This report aims to assess the predictive power of the IPI for HL patients. On the basis of the retrospective study of patients with HL, we analyzed the prognostic significance of several factors with regard to response to treatment. We reviewed the medical records of 26 patients with HL, who were diagnosed and treated in our Clinic between 2004 and 2008. The median age of patients was 40 years, out of which 61.7% were males. Most patients had nodular sclerosis (57.7%) and mixed cellular (38.5%) histology. Clinical stage at diagnosis (AAS) was: I II 46.1%, III IV 53.9%. Presentation of IPI score was: low 26.9%, low intermediate 30.8%, high intermediate 34.6% and high 7.7%. B-symptoms were recorded in 64.5% of patients. Most of the patients received standard multi-agent chemotherapy with the well-established ABVD regime which provides the best balance of effectiveness and minimization of toxicity. Complete remission (CR) was achieved in 69% of patients after the first-line therapy. Significantly associated with the decrease of probability of achieving CR was the increased IPI score itself (p=0.02) and two of the five factors analyzed: extranodal disease >1 site (p=0.003) and poor performance status >1 (p=0.04). The International Prognostic Index shows good prognostic power in HL.
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تاریخ انتشار 2008